Regulation of Cell Cycle
Cell cycle checkpoints
The G₁ checkpoint is the most important
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Internal regulators: cyclins and CDKs
Cyclin-dependent kinases (CDKs)
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Cyclins
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How they work together
MPF (Maturation-Promoting Factor)
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External regulators
Growth factors
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Density-dependent inhibition
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Anchorage dependence
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Growth inhibitors
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Cancer: loss of cell cycle regulation
Characteristics of cancer cells
Proto-oncogenes → oncogenes (review from 4.4)
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Tumor suppressors (review from 4.4)
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